8 ideas for experienced teachers who want a second career

8 ideas for experienced teachers who want a second career Teaching is both rewarding and difficult. There’s a lot to love about the profession, particularly having a front seat to witness students growing and learning throughout the school year. But over the long term teachers can get worn out- and are often overworked for little pay. The good news for experienced teachers is that the profession comes with a number of translatable skills. In addition to particular subject area knowledge, experienced teachers possess excellent public speaking, presentation, and leadership skills, and establish themselves as effective communicators- not just with school-aged populations, but also among parents, colleagues, and administrators. Teachers are also adept at detail-oriented work like editing, long-term planning of activities, and meeting educational goals.If you’re looking to leave the traditional classroom, the skills you’ve acquired as a teacher are can translate to many jobs in varying fields. Let’s look at a few.8 no n-classroom jobs for teachers1. Employee training/HRMany companies offer workshops, new employee training, and orientations, and need someone to run them. These employee training activities require someone with a similar skillset to teaching. Often housed in the HR Department, the presentation and transfer of knowledge in a corporate setting can offer experienced teachers a place to use their communication skills to help employees learn about their company and enrich their experiences at work.2. School administratorWhether in the area of running the day-to-day business of the school or assisting in curriculum development, teaching experience is a boon for any administrative position. From school principals to university registrars, there are a variety of positions that help keep a school running, and most positions require advanced degrees. This is a good position for teachers who are devoted to the educational system, but worn out on teaching in the classroom.3. Residential life c oordinator/Youth organization directorThe organizational skills required to plan a year of lessons and be flexible minute to minute in the classroom translate well to camps, youth organizations, and residential life departments of college campuses. Teaching experience means you will be adept at the long-term planning required in these roles, and familiarity with specific age groups in a classroom setting gives you a leg up, as you must show you can deal with large groups of people and keep them organized and engaged.4. Freelance writing and editingTeachers’ communications skills translate well to writing and editing positions, where they can use their expertise to educate outside of the classroom. Writing offers more flexibility than teaching, but less job security- especially as most writers work on a freelance basis. Editing positions, where a teacher can be called upon as a subject-matter expert to review and offer advice on their topic of knowledge, are another great free lance opportunity.5. Guidance counselorGuidance counselors must have specific knowledge about school-age populations, testing, and school district guidelines, as well as the ability to tap into a student’s motivation. Teachers already know how to do this well. In most cases, guidance counselors need to be licensed, and in some states, they need to have a master’s degree. While this job is very much adjacent to the classroom, as the primary goal is guiding students toward their educational goals, the change from classroom to office is a big one. Even so, you’re still in a school setting so that the career will feel s.6. Academic librarianExperienced teachers fit well into the role of librarian, as they have experience engaging with students while helping them in educational settings. In academic libraries, there are subject librarians with particular knowledge in certain areas (similar to teaching) that help students and faculty find resources to help with their research. Academic librarians often give presentations or build websites for university classes to help them learn how to use library tools. This role requires a graduate degree in library and information science, but for teachers looking to make a career move it can be a great option.7. Event plannerLarge-scale events, from evening receptions to corporate meetings, require a lot of planning over months and need planners with ability to think on their feet to make sure the day of the event runs smoothly. As they coordinate speakers, catering, and venue staff, event planners must be detail-oriented, effective communicators who are comfortable with large groups. While a departure from teaching, running a big event and coordinating all the details requires a similar skillset and can be a new avenue for a teacher looking to embark on a totally different career.8. Teaching outside the classroomEssentially â€Å"freelance† teaching, this option offers educators the ability to set t heir own schedules. Beyond the traditional classroom setting in schools, there are growing opportunities for online teaching or tutoring one-on-one or in small groups. Educators who don’t want to branch out on their own can also work through an agency. For teachers who have frustration with the school system but still have the teaching bug, this route can provide more freedom while still changing students’ lives.

Valuable Leadership Experience

Valuable Leadership Experience Business managers are increasingly finding themselves being replaced by business leaders. The difference between a leader and a manager is that while a manager views the job as a career, a leader perceives it as a calling and a personal responsibility.Advertising We will write a custom essay sample on Valuable Leadership Experience specifically for you for only $16.05 $11/page Learn More There are many traits that differentiate between a manager and a leader, but the most significant element is their role since the duty of a manager is to manage, while that of a leader is to lead. Unlike managers, leaders attract their follows by earning their trust and through motivation. In my professional career, I have had several opportunities not only to be a manager, but also to exercise my leadership skills. This essay endeavors to describe one such occasion. Our company strategized to formulate a method through which our major clients would be transited for GAAP to IFSR. The company executives preferred internally bred solution. Thus, we were divided into teams, each with a leader and a mentor. The teams were to present their findings to the judges who were the company executives in a span of two weeks. Ken, an extremely respected business leader was my team leader. However, his packed schedules did not allow him time to convene our group within the first week. Upon realizing that we were running out of time, I decide to convene our first meeting with our mentor to map the way forward. This first meeting was not very successful as my team members did not have the necessary knowledge on the case we were working on. This influenced our mentor to be very skeptical of our team’s ability. That is when I decided to take full responsibility of the project. I rallied my team members and within a short time, we had a workable project plan, comfortable with all members. I then identified the special talents in each of my team members and assigned them responsibilities concurrent with those talents. This proved very useful in improving team efficiency. Prior to every meeting, I did extensive research on the case and summarized my findings. These findings provided my team with necessary information it needed. I had to provide the general direction, thus giving each member space for creative involvement in the task. The fact that we were short of time motivated team members to work diligently in their areas of responsibly and reporting to the group on the progress made. The task was not only completed in time, but was also voted as the best. It was a task accomplished successfully within limited time and under dedicated leadership and teamwork.Advertising Looking for essay on business economics? Let's see if we can help you! Get your first paper with 15% OFF Learn More Our project provides several valuable lessons on leadership. Leaders must develop the trust of team members and their abilities to acco mplish the task. Other than provide general direction, they should also provide the necessary resources to the team. In our case, knowledge was the resource the team members needed. They also recognize and allocate duties according to team member’s abilities, while letting them be creatively involved in the task. Generally, they make every member feel appreciated and valued by the team.

EU and the transport policy Essay Example | Topics and Well Written Essays - 2000 words

EU and the transport policy - Essay Example Furthermore, the creation of one market or single market like the EU needs a well developed transport industry. Policies play an important role in shaping a transport industry which will increase the economy of the countries involved. The EU Transport Policy The policy adopted by the EU seeks to find ways of creation of an economical transport sector so that it can curve in major challenges in the industry like road congestion, barriers to transport systems and emission of green house gases such CO2. Additionally, the policy helps in the creation of infrastructure for the transport industry, investment in the industry and innovation. Furthermore the use of fossil fuels by the machines in the transport sector is also addressed by the policy. The policy was meant to tackle challenges facing EU nations with regard to the transport sector like road congestion and cross-border tariffs. This paper will address the policies made by the EU for the transport industry and the achievements they have made since the creation of such policies (Rodenburg et al 2002). The European countries came together with policies for transport systems such as roads, rail and inland waterways. The EU common markets pushed for a common transport policy because they encouraged free movement of goods and people throughout Europe. The policy signed in 1957 called the treaty of Rome was meant to allow free movement of goods and people across all the nations in Europe but the policy was not taken seriously until 1980 (Ionescu, 2012). The policy was only put into use after a court process which took place in 1983 involving the European Parliament and the Council of Ministers. This increased the process of the formation of a single market involving European countries with the inclusion of transport in the act which was signed. Ionescu (2012), shows that the signing of the single treaty made many changes in the transport industries which also gave a chance for Europeans countries to work together a cross different states. The treaty signed was also meant to address cases of environmental degradation caused by pollution. The policy was for the development of rail, road and waterway structures. This is because there had been disparities in transport systems in European countries with most Western countries having better and well developed transport systems, mostly high-speed rail systems, than that of the Eastern European countries. Furthermore the policy was made to address environmental challenges as mentioned above. The main target of the policy was to address the development of the rail system, roads and waterways. The combination of the three transport systems is referred to as the Transport European Networks (TENs). The European Union transport policy was made to tackle the creation of transport infrastructure which would link Eastern and Western Europe. This was later addressed in a white paper singed in 2004. The policies in the white paper were later changed in 2011 to make three changes by 2050. For example, the EU is to stop the use of more fossil fuel and find alternative energy, increase the use of the rail system, and use fuel in the aviation industry producing less than 40% carbon. The policy was meant to ease movement of freight and people across national boundaries hence the border tariffs would be removed (Ionescu 2012). The EU is committed in applying the set policies and has so far achieved the set targets. Goals of the EU policy The reduction of

Tourism in the Kingdom of Jordan Case Study Example | Topics and Well Written Essays - 1500 words

Tourism in the Kingdom of Jordan - Case Study Example It is a small Arab country with not much supply of water and other natural resources like oil. Debt, poverty, and unemployment are fundamental problems, but since 1999, some broad economic reforms have been in place in a long-term effort to improve living standards. Under the leadership of King Abdullah, Jordan's government has taken some concrete steps towards encouraging foreign investment in the country. Key areas where maximum attention is being paid include tourisms and services. The country's economy largely depends on services, tourism and foreign aid. Tourism in general is being developed the world over as a revenue spinning industry Jordan too has an ambitious plan for inviting the attention of the world's touring community towards its vast historic treasures and nature's gifts to the country. Thourhg this study we'd like to analyse; Tourism being one of the key sectors for Jordanian economy, the government of Jordan has realized the potential of this rapidly growing sector, and the government is supporting the industry with aggressive marketing strategy with an aim to promote Jordan as a boutique destination. Despite being in the midst of disturbed surroundings the number of regional tourists is rising sharply. Now the government is paying more attention towards attracting the high-yield visitors from outside the Middle East. In this era of globalisation, tourism is said to drive transnational flows of people, commodities and capital. This flow results in circulation of globally coordinated production networks governed by Multi national corporations in the business of airlines, tour operators and hotel management (Hazbun, 313). As per the studies undertaken by organisation like CountryWatch (83) and Country Insight (3), the flow of tourists has been on an upward journey. The figure below takes a look at the num ber of tourists that arrived in the region for the period 1998-2004. Until the late 1990s Jordan's tourism sector remained hugely underdeveloped, with regional political instability doing most of the damage. Since there was no real effort on the part of the government of Jordan to come out of the shell and market the potentials of the country, the region remained largely un-explored. But with the concepts of globalisation have now made the government understand the benefits of being pro market. In fact Jordan realizes (EIU, 1) that it can't be a direct competitor for other popular Arab holiday destinations like Cairo or Beirut, but now Jordan has actually started selling its holiday proposition by way of offering quiet family holiday. This has materialized in earning revenues as well, which is reflected by some of the key points of tourism industry in Jordan like (Euromonitor, 2); Jordan received US$783 million in tourism receipts in 2004 and this is expected to rise to US$826 million in 2005. Tourism accounts for around 10% of the Kingdom's GDP. Tourism is the largest export sector, the second largest private sector employer and the second most important form of foreign exchange for the country. The

Discuss the rationale behind letters of credit with emphasis on the Essay

Discuss the rationale behind letters of credit with emphasis on the fundamental principles underlying these instruments. Critica - Essay Example Credit letters are used in cross border business transactions to make sure that payment will be received. The adoption of letters of credit has become extremely essential in cross border trade due to the nature of international dealings such as varying laws and difficulty in knowing each trade party personally. Additionally, the bank acts on buyer’s behalf by making sure that a seller will not receive payment pending the bank’s verification that goods have been dispatched. The parties to a letter of credit comprise of three or more persons. These are; the account party (importer/ applicant/ buyer), the issuing bank (the applicant bank) and the beneficiary (exporter/seller) (Gilles & Moens, 1998, p 395; DiMatteo, 2009, p 100). There exist contractual associations while using letters of credit in global business among the most essential parties, that is the issuing bank (one making payment of the applicant’s behalf), to the beneficiary, and the paying bank (in situ ations where there is a correspondent), the advising bank, as well as the confirming bank. Ideally, they are same bank but given different terms. As such, several contractual relationships are distinguishable. One is the contract between the applicant and the beneficiary. Two is the relationship between the applicant and the issuing bank. ... This is usually a letter drafted and signed by bank acting on the applicant’s behalf, addressed to the beneficiary. The applicant bank will agree to drafts under credit simply if the beneficially adheres to conditions set forth in the credit letter. The beneficiary is also requested to hand in certain deeds like commercial invoices and insurance papers in addition to the draft and other documents that may be specifically needed. The issuing banks acts on behalf of the buyer (applicant) in paying the beneficiary provided that all terms stipulated in the letter are adhered to (Ramlogan & Persadie, 2004, p 14). Source: Michigan law review, p 406 Documentary credit letters can be classified into: Transferable or non-transferable A beneficiary in the credit letter often maintains on an express term in the contract clarifying that the credit is â€Å"transferable†. The main upshot of a transferable letter of credit is that the seller (beneficiary) may request the designated b ank to transfer credit to the beneficiary’s supplier. However, the designated bank is under no legal obligation to transfer credit. The UCP affirms that a credit letter is transferable only if the contacts states so, the absence of which the beneficiary cannot insist that the designated bank to transfer credit (Moens & Jones, 2008, p 39). Revocable and irrevocable A revocable letter can be rescinded by the bank responsible for issuing at any time without preceding notice to the seller. The contract has to specifically state that a credit letter is revocable; otherwise it will be considered unalterable. A beneficiary seller in cross border transaction needs payment security, apparently not prepared to accept revocable letter of credit, since this would result

Microbiota and Cancer Treatment

Microbiota and Cancer Treatment Chloe Duffy Abstract microflora in humans regulates numerous bodily processes and cellular functions metabolism, inflammation, immunity, and now has been found to play a role in cancer treatments efficacy, side effects, after effects. talk about the body of the paper. In conclusion, the gut and potentially oral, etc microbiota can be modulated to protect the body from effects of treatment, or even enhance the effectiveness of the treatment. Introduction The human body contains numerous microorganisms that inhabit many parts of the body such as the skin, oral mucosa, and gastrointestinal tracts, known as the human microbiota. These microorganisms aid in metabolism, local and systemic immune system responses, regulation of inflammation, nutrient absorption, and even prevention of infection and diseases. Some of the most common bacteria within the gut microbiome are Firmicutes, Bacteroidetes, Bifidobacteria, Proteobacteria, Verrumicrobia, Actinobacteria, Fusobacteria, and Cyanobacteria; other types of bacteria such as Actinomyces or Lactobacillus are also common in other areas of the body. All of these types of bacteria play a role in different processes that are beneficial to maintaining health. Although these microorganisms are commonly found in most individuals, each hosts microbiota is unique. Genetics, antibiotic use, diet, type of birth delivery, lifestyle, and incidence of disease can all contribute to the composition of gut mic robiota.12   Although this means that the gut microbiome is variable and certain conditions can result in dysbiosis, it is also beneficial to have the capabilities to modulate and control the gut microbiota in order to maintain healthy bodily functions and immune responses to infection. Recently, there have been studies establishing a relationship between microbiota and cancer treatment. Particularly the gut microbiota that influences metabolic functions and inflammation and adaptive immunity play a major role in the initiation, proliferation, and response to anticancer treatment.12 In the majority of studies, the microbiota have been shown to enhance the effectiveness of cancer treatments and prolong the anticancer immune response. One way this has been demonstrated is by the transfer of faecal microbiota from mice that respond well to cancer therapy into unresponsive germ-free mice, resulting in improved anticancer reactions to treatment. Research has also shown that predictions can be made based on the patients gut microbiome whether or not they will have an efficient reaction to the cancer treatment or if they will exhibit negative side effects from the method of therapy.8 In addition to using the microbiome to predict patient reactions to therapy, studies have shown that it is possible to modulate the gut microbiota in order to either prevent or treat adverse effects that usually coincide with different therapies.19 These new developments are crucial for the progression of cancer therapies, especially immunotherapies. Many patients still do not respond to anticancer treatments that others do and with this promising research new opportunities for personalized therapy become an option for these individuals. Immunotherapies and modifying the microbiota of patients can offer more tailored treatment plans that can provide more promising results. In addition, these new methods can enable a more aggressive treatment plan for certain types of cancer without the fear of negative side effects or lasting damage to healthy tissue. With modulation of the microbiota, these adverse effects can be prevented and treated, using the microorganisms to protect against injury. The composition of the human microbiota plays an integral role in regulating the efficacy of anticancer treatment and development of adverse effects. (Should I include that targeting the microbiota can improve the efficacy and reduce adverse ef fects? Human Microbiome and Cancer Treatments       There are many different categories of anticancer therapies, the three main types are chemotherapy, radiation therapy, and immunotherapy. However, there is interindividual variation in the gut microbiota that can determine whether the immune system is competent enough and if the patient will respond to therapy positively or negatively.19 The targeting of gut microbiota can improve the efficacy of all of these treatment plans. The figure below shows some of the processes that gut microbiota can regulate anticancer therapies. Figure 1 12 This figure is an overview of a selection of anticancer treatments that the gut microbiota can mediate or perhaps enhanceà ¢Ã¢â€š ¬Ã‚ ¦ add more descriptionà ¢Ã¢â€š ¬Ã‚ ¦ Chemotherapy Chemotherapy is the use of drugs, usually cytotoxic, to treat cancer. These cytotoxic drugs are typically classified according to their mechanism of action, alkylating agents, heavy metals, cytotoxic antibiotics, and spindle poisons.12 These drugs cause significant damage to any rapidly dividing cells including healthy tissues, and can therefore have varying effects on individual patients. Gastrointestinal toxicity is a common adverse effect from anticancer drugs and can be so severe that the treatment has to be postponed or the dose is limited; this reduces the efficacy of the therapy. Targeting and modifying gut microbiota can be used to protect the intestinal epithelium and prevent the toxicity of these compounds. One mechanism of microbiota that can be exploited is its role in drug metabolism and microbial enzymatic degradation. An example of this is with the drug Irinotecan. Irinotecan is a chemotherapy drug that commonly causes severe gastrointestinal distress by increasing caecal Clostridium cluster XI and Enterobacteriaceae and cannot be used long term for treatment. SN-38, the drugs active metabolite is converted to glucuronide which is typically cleaved by bacterial beta-glucuronidases, commonly found in the Firmicutes phylum, for a carbon source; however, this releases the active SN-38 back into the intestinal lumen leading to diarrhea.19 In this study, however, it was discovered that the bacterial enzyme has a specific loop not present in the human enzyme; this is beneficial in developing drugs to target the bacterial enzyme specifically in order to prevent the adverse effects to continue anticancer treatment. Ciprofloxacin and amoxapine were two drugs that exhibited inhibition of the bacterial enzyme, suppressing the severe diarrhea.19 The microbiota enzymatic functions can also have a role in modifying the toxic profile of chemotherapy drugs. This can cause difficulty in creating custom chemotherapy treatment plans utilizing the modulation of microbiota because some of the bacteria can have multiple effects on different targets using the same enzyme. An example of this is the bacterium Mycoplasma hyorhinis, it contains a phosphorylase that can restrict the ability to inhibit cell growth and division by drugs containing pyrimidine nucleoside. Additionally, Mycoplasmas phosphorylase negates the efficacy of the drug gemcitabine. However, this same enzyme can improve the effectiveness of drugs containing the metabolite 5-fluoro-5-deoxyuridine.19 This proves the difficulty in modifying each patients gut microbiota to improve their chemotherapeutic efficacy. Although, it can be useful and can allow the treatment plans to continue without termination due to adverse e ffects, it will require much more research for each individual drugs reaction with gut microbiota enzymes. The gut microbiota can also indirectly affect the metabolism of chemo drugs through modifying gene expression and the physiology of the mucosal barrier in the intestines and liver. In one study, germ-free mice were compared with conventionally raised mice and mice given a probiotic. The germ-free mice exhibited altered gene expression to increase the rate of metabolism of many xenobiotics, whereas even after recolonization of the germ-free mice and administration of a probiotic, not all of the altered genes returned to normal gene expression.12 This raises the observation that not only does the differences in composition of microbiota and their enzyme function play a role in drug metabolism, the activity and lifestyle between individuals matters as well. Immunomodulation and affecting the tumor-microenvironment are two additional ways that the gut microbiota have been found to modulate chemotherapeutics. Cyclophosphamide is a drug that works through many different immunological pathways, stimulating the antitumor immune response.This drug alters the composition of the microbiota in the small intestine and induces the translocation of certain gram-positive bacteria into secondary lymphoid organs.16 Once the bacteria are translocated into the lymphoid organs, they can stimulate an immune response of T helper17 cells and memory TH1 cells. The translocation of the bacteria, typically Lactobacillus johnsonii, Lactobacillus murinus, and Enterococcus hirae, takes place because cyclophosphamide causes discontinuity of the intestinal barrier allowing these microorganisms to relocate to the secondary lymphoid organs. A gram-negative bacteria, Barnesiella intestinhominis is also involved in this chemotherapy drug; it   was shown to incre ase the systemic levels of cytotoxic CD8+ T cells and TH1 cell responses. This bacteria was also proven to activate IFNgamma-producing lymphocytes that are tumor-inflitrating.1 The role gut microbiota plays in the efficacy of cyclophosphamide treatment and immunomodulation was demonstrated by the use of germ-free mice and mice that were treated with antibiotics. The mice that were pre-conditioned with antibiotics proved to inhibit the anticancer effects of the chemotherapy drug and no reduction in the tumor size. Similarly, the germ-free mice had less pTH17 responses and their tumors were unchanged by cyclophosphamide. However, transfer of pTH17 cells restored the efficacy of the anticancer drug.1 These results show that the gut microbiota not only play a role enzymatically and through drug metabolism, but that the microbiome is used to activate the anticancer immune response. This is critical knowledge for the progression of immunomodulation with chemotherapeutics, and gives insight as to why not all patients may react the same to this type of treatment. However, modification of the gut microbiota can enhance the efficacy and response in the patients that typically do not show change in the tumor size. Gut microbiota can also affect the tumor microenvironment in correspondence (à ¯Ã†â€™Ã… ¸is that the right word?) with chemotherapeutics. Oxaliplatin and cistplatin treatments cause tumor cytotoxicity by forming intra-strand platinum-DNA adducts that lead to DNA double stranded breaks; reactive oxygen species is also involved in the damage of DNA. Although these methods are effective for creating an antitumor environment, it also causes severe damage to intestinal mucosal cells which can cause septicemia and systemic infection.12, 10 In germ-free mice the drug oxaliplatin did not induce as great of an inflammation response and consequently the antitumor efficacy was reduced, showing that inflammation is important in the drugs antitumor response. The induced DNA damage within the tumor cells was also reduced, however oxaliplatin was still able to enter into the tumor to form fewer of the platinum-DNA adducts.16 Another effect the microbiota have on these chemo drug antitumor mechanis ms was shown in germ-free mice, the production of ROS was inhibited without gut microbiota. This was previously thought to come from the cancerous cells, however the microbes prevented ROS production through tumor-infiltrating myeloid cells via NADPH oxidase 2.12 This is important to note because this shows that oxaliplatin will not be effective without gut microbiota or depleted myeloid cells. Oxaliplatin also works by inducing immunogenic cancer cell death, this can be achieved by exposing the cell surface- associated immunostimulatory signals, activating antigen-presenting cells which create and antitumor response.With a combination of activation of TLR4, DAMPs from the dying cells, and NLRP3 inflammasome, these can mediate the adaptive T cell-mediated response against the treated tumors.10 When mice are depleted of their microbiota, these cytotoxic and immunogenic effects are decreased, along with the efficacy of tumor reduction. These results demonstrate that gut microbiota can play a role in the cytotoxic effects of DNA damage and inflammation, but also can affect the adaptive immune response to cancer. Gut microbiota has an influential role in the efficacy, toxicity, and outcome of chemotherapeutics. Radiation Therapy Radiotherapy can consist of cancer patients receiving ionizing radiation therapy (RTX) that is typically for localized cancers, or total body irradiation (TBI) that is usually used in preparation for bone marrow transplants or adoptive T cell transfer immunotherapy. These can be effective treatment routes, however, there is a bystander effect on nearby cells that can cause inflammation, immune reactivity, and genome instability.12 These effects do not necessarily occur directly from the DNA damage caused by radiation, these typically are a result from disruption of gap junctions, and release of ROS, NO, cytokines, exosomes, and DAMP stress signals. There are just now beginning to be more studies done about how exactly microbiota can regulate the hosts response to ionizing radiation therapy. It is difficult to study because the effects from radiation can cause a myriad of reactions within the body; some of these effects can be immunostimulating while others can be immunosuppressive. When a patient receives radiotherapy, the antitumor signals are not just contained to the localized area of the tumor; there are antitumor responses that occur that are immune mediated and activate antigen-presenting dendritic cells and T cells. Therefore, because microbiota have been shown to mediate and affect the immunogenic responses in chemotherapy and immunotherapy, it is reasonable to believe microbiota play a role in the immune system responses due to radiation. One of the major limitations to radiotherapy is the safety concern for the patient while balancing the antitumor effectiveness of receiving ionizing radiation therapy. Different cance r types will have different radiation sensitivities as well as the local and systemic toxicity and stress responses that have potential to cause significant injury or impair the antitumor immunity.12 Receiving ionizing radiation therapy is associated with damage to rapidly proliferating tissues such as epithelia, like the digestive tract mucosa, and bone marrow. These adverse effects can cause oral mucositis, diarrhea, and inflammation in the gut and can create gut microbial dysbiosis.12 A recent study investigated whether or not a faecal microbiota transplantation would protect against radiation-induced toxicity.They were able to come to the conclusion that faecal microbiota transplantation did in fact increase the survival rate of mice; in addition, the faecal microbiota transplant increased the peripheral white blood cell counts, maintained the intestinal epithelial integrity, and preserved the gut microbiota composition in mice that had been irradiated.7 Using the strategy of faecal microbiota transplantation could greatly improve the outlook for   radiotherapy patients, it can reduce injury to healthy tissues and improve patients prognosis after radiotherapy. The component that regulates irradiation-mediated intestinal toxicity is the TLR3 for double-stranded RNA. Knockout mice without Tlr3 are actually protected from TLR3-dependent cell death post radiotherapy, despite being sensitive to p53 dependent radiation-induced apoptosis. These knockout mice also survive longer and have less damaging effects on their intestines than wild-type mice. These results would suggest that blocking the TLR3 signaling could reduce the radiation-mediated gastrointestinal damage.12 In this study they also demonstrated that the DNA double stranded breaks, induced from radiation anticancer treatment, also activate a DNA receptor that is not present in melanoma 2 inflammasome; this would result in tissue damage and cell death. However, the bacterium Lactobacillus rhamnosus GG, a probiotic, has demonstrated  protection of the intestinal mucosa from radiation therapy-induced toxicity. This probiotic does this by using a TLR2/MyD88 signaling mechanism to reposit ion cyclooxygenase 2- expressing cells from the villi to the base of the intestinal crypts which induces reactive oxygen series, leading to activation of the NRF2 system; this system is cycloprotective.6 Therefore probiotics have some capabilities to prevent radiation-induced enteropathy. The probiotic composition that studies have found to be most beneficial are Lactobacillus acidophilus, B. bifidum, Lactobacillus casei, Bifidobacterium, Lactobacillus and Streptococcus spp.5 For clinical purposes, these probiotics can be used as a prophylactic strategy to limit the intestinal injury. All of these microorganisms have been proven to protect against gut toxicity from radiation anticancer treatments; this is greatly beneficial to the patients so they do not have to endure adverse effects, such as severe diarrhea, and can continue the treatments to increase their antitumor effectiveness. In contrast, some studies suggest that it is possible to predict whether or not a patient is going to have adverse effects to radiotherapy based off the presence of gut microbial dysbiosis or a well-balanced gut microbiome. They used pyrosequencing analysis of 16S rRNA gene to reveal the microbial diversity in the hosts gut microbiome. The individuals that had a significantly altered Firmicutes/Bacteroidetes ratio before the radiation cancer treatment, later developed diarrhea as an adverse effect from treatment. These results indicated that gut microbial dysbiosis before radiation antitumor therapy can be utilized to predict if the patient will develop adverse effects from treatment such as diarrhea.18 This knowledge could guide treatment plans to be tailored for the individual and could allow for preventative treatment options. Total body irradiation is usually used as a preparatory process for another type of anticancer treatment such as a bone marrow transplantation or adoptive T cell transfer immunotherapy. Contrary, to the logic of many of the studies in this review, germ-free mice were shown to survive longer than conventionally raised mice after total body irradiation, and actually required a higher dosage of radiation to induce intestinal disease and mortality.7 The germ free mice were reported to have less apoptotic cells of the intestinal mucosa and even less lymphocyte infiltration than the mice with regular gut microbiota.7 They hypothesized that this could be due to the germ-free mice having no gut microorganisms that could trigger mucosal inflammation or create damage from the radiation insult. One mechanism they were able to identify that contributed to the germ-free mice resistance to total body irradiation was the production of angiopoietin-like 4. This is a protein inhibitor of lipoprotein lipase that is normally suppressed by normal gut microbiota in the conventionally raised mice.12 This angiopoietin-like 4 protein, when knocked out of germ-free mice, causes the mice to be susceptible to the same intestinal damage as conventionally raised mice that block angiopoietin-like 4 protein. Interestingly, the transcription of angiopoietin-like 4 gene is regulated in response to certain gut bacteria; however, these same bacteria that induce angiopoietin-like 4 expression include Bifidobacterium, Lactobacillus, and Streptococcus spp. that also mediate the protection against the localized received ionizing radiation therapy.12 This can provide an explanation for although most studies have shown that mice treated with probiotics and have a healthy microbiome are resistant to radiotherapy toxicity, germ-free mice can provide some resistance as well. Although most of these studies focus on the gut microbiota, there are studies that reveal how the oral microbiota can effect prediction of enteropathy as well from radiotherapy for  nasopharyngeal carcinomas. Rather than diarrhea as an adverse effect from pelvic radiotherapy, oral and oropharyngeal mucositis are the most common side effects of radiation anticancer therapy for head and neck cancers.20 Similarly to using gut microbial dysbiosis to predict whether the patient would develop adverse effects from treatment, the same can be done with analyzing the oral microbial community and its correlation with radiation-induced mucositis. The results demonstrated that patients with a higher percentage of Actinobacillus exhibited severe mucositis later on after treatment.20 Their findings also showed, similarly, that they can predict future incidence of mucositis during radiotherapy based on the oral microbiota prior to treatment. This is significant because not only can this applicatio n be applied with gut microbiota, it can be applied with the oral microbial community and many others throughout the body corresponding to different types of cancer. Immunotherapy Immunotherapy approaches are currently a popular topic to study and these immunological therapies have shown great potential in long-lasting responses. The efficacy of this type of treatment, however, is limited more than radiation therapy or chemotherapy because of the vast difference in immune responses of individual patients and the susceptibility of different tumor types. However, with new information about the ability of gut microbiota to modulate the hosts response to immunotherapy, it is possible to further study the possibility of improving immunotherapy efficacy by targeting these microbiota. One of the first examples of gut microbiota maintaining the anticancer effect of immunotherapy, was the demonstration that the efficacy of adoptive transfer of tumor-specific cytotoxic T cells following total body irradiation was reduced in mice treated with antibiotics.12 After the total body irradiation causes the translocation of microbiota into the secondary lymph nodes, the prolife ration of the transferred T cells in the tumor and their antitumor activity was enhanced. CpG- oligodeoxynucleotide intratumor therapy is an immunotherapy that uses the TLR9 agonist CpG- oligodeoxynucleotide to induce an antitumor effect. The antitumor effect is then increased when the immunosuppressive effect of IL-10 is prevented by using the IL-10 receptor antibodies. This method induces the secretion from myeloid cells of tumor necrosis factor and IL-12 that in turn cause hemorrhagic necrosis and can redirect tumor-infiltrating macrophages and dendritic cells from and anti-inflammatory to a pro-inflammatory state.12 There is an antigen-specific T cell antitumor that is elicited within this pro-inflammatory environment which results in the clearance of tumors in conventionally raised mice.12 This is not the case in germ-free mice or mice that have been treated with antibiotics. In these mice the tumors treated with CpG-ODNs and anti-IL-10R progress and the immunotherapy is inefficient. Finally, if the mice have a low amount of microbes, the myeloid cells do not produce pro-inflammatory cytokines and the TNF-dependent hemorrhagic necrosis and antitumor immunity are not induced.12 In these tumors, of microbiota-depleted mice, the amount of infiltrating inflammatory monocytes before treatment were unchanged but the number of Ly6C+ major histocompatibility complex class II+ were reduced. This suggests that the differentiation of infiltrating inflammatory monocytes into macrophages and dendritic cells is impaired. After CpG-oligodeoxynucleotide treatment, there are major differences in the gene expression of TNF and IL-12 in tumor-infiltrating myeloid cell  subsets between microbe-depleted and conventionally raised mice.12 There is another reduction in the response to this treatment from TLR4 -deficient mice, however, treatment with the TLR4 agonist LPS to the microbe-depleted mice reinstitutes the responsiveness of the myeloid cells.12 The results from this study demonstrate that the gut microbiota primes the myeloid cells for sensitivity to TLR9. Another study using CpG-oligodeoxynucleotides showed that the CpG-ODNs correlates with the frequency of different genera in the faecal microbiome of mice at the time of treatment.12 Allistipes and Ruminococcus are positively correlated with TNF production, however, Lactobacillus fermentum, Lactobacillus murinum, and Lactobacillus intestinalis are negatively correlated, meaning when one of the bacteria from the genera Lactobacillus were administered, there was an impairment of TNF production.12 This indicates that different types of bacterial species can have opposite effects; therefore, using antibiotics, prebiotics, or probiotics, can change the gut microbiota composition or frequency resulting in mediating the hosts response to immunotherapies. The use of immune checkpoint inhibitors is a final immunotherapy method that has been greatly studied and researched. In the majority of patients, the antitumor immune response is suppressed but can be reactivated by the release of certain signal factors. The immune checkpoint inhibitors, which are antibodies against the cytotoxic T lymphocyte-associated antigen 4 and programmed cell death protein 1 or its ligand PD1 ligand, exhibit strong antitumor activity in animal models and even long lasting clinical efficacy in cancer patients.12 Although this is a promising therapy, there is always the concern of variation of response between patients and between different types of cancers. These checkpoint inhibitors can also induce adverse effects such as colitis and inflammation of the pituitary gland in response to the cytotoxic T lymphocyte-associated antigen 4 antibodies, and thyroid dysfunction and pneumonitis after the blockade of the PDL1-PDL1 interaction.14, 15 Two recent studies investigated the influence gut microbiota has on this type of immunotherapy, specifically how anticytotoxic T lymphocyte antigen blockade requires Bacteroides spp. and how Bifidobacterium spp. enhances the effectiveness of antiprogrammed cell death ligand 1 therapy.14, 15 In the first study, in mice and patients the T cell responses specific for B. thetaiotaomicron or B. fragilis correlated with the effectiveness of CTLA-4 blockade. This was confirmed because the tumors in the germ-free mice did not respond to the CTLA blockade, but when the mice were treated with B. fragilis, this defect was overcome.15 The second study compared melanoma growth in mice with particular commensal microbiota and then observed the differences in antitumor immunity. They then sequenced the 16S ribosomal RNA which identified Bifidobacterium as associated with the antitumor effects. The administration of Bifidobacterium improved the tumor control as much as the programmed cell death prot ein 1 ligand 1- specific antibody treatment, and combination treatment almost ceased tumor growth.14 The results from these studies demonstrate that the mechanism of how anti-PDL1 treatment improves the antitumor immune response does not have to include microbiota inflammation and immune activation, like what is induced by anti-CTLA4. Anti-CTLA4 may alter the composition of the gut microbiota that favors its own antitumor activity. Yet, the effectiveness of the anti-PDL1 therapy is aided in hosts with a pre-existing antitumor immune response if Bifidobacterium spp. are within the gut microbiota.12 Microbiota and Lasting Effects from Treatment After the use of cancer treatments, many times there can be lasting effects even into adulthood from childhood cancer therapies. This study demonstrated that restoring the microbial diversity in patients suffering from immune dysregulation, as a result from childhood acute lymphoblastic leukemia, could reduce chronic inflammation and reduce development of late adverse effects.4 They observed that adult survivors of childhood ALL all had microbial dysbiosis or lack of microbial diversity. The composition of host microbiota is crucial to immune activation, for example T cell activation and increased levels of IL-6 and CRP. Therefore, they hypothesized that the microbial dysbiosis was related to the background chronic inflammation in adult survivors. Additional studies would have to be performed to determine causation, but this study creates the possibility that therapeutic interventions that restore microbial diversity to the ALL survivors could help to reduce the long-term negative ef fects. Further research would need to be done to determine the proper mechanism to restore healthy microbial diversity to humans.   Ã‚   Figure 2 1 References 1. Alexander JL, Wilson ID, Teare J, Marchesi JR, Nicholson JK, Kinross JM. Gut microbiota modulation of chemotherapy efficacy and toxicity. Nature Reviews Gastroenterology Hepatology. August 2017. doi:10.1038/nrgastro.2017.20. paper 10 2.Bultman SJ. Emerging roles of the microbiome in cancer. Carcinogenesis. 2013;35(2):249-255. doi:10.1093/carcin/bgt392. paper 17 3. Champer M, Wong AM, Champer J, et al. The role of the vaginal microbiome in gynecological cancer: a review. BJOG: An International Journal of Obstetrics Gynaecology. 2017. doi:10.1111/1471-0528.14631. paper 9 4. Chua LL, Rajasuriar R, Azanan MS, et al. Reduced microbial diversity in adult survivors of childhood acute lymphoblastic leukemia and microbial associations with increased immune activation. Microbiome. 2017;5(1). doi:10.1186/s40168-017-0250-1. paper 7 5. Ciorba MA, Riehl TE, Rao MS, et al. Lactobacillus probiotic protects intestinal epithelium from radiation injury in a TLR-2/cyclo-oxygenase-2-dependent manner. Gut. 2011;61(6):829-838. doi:10.1136/gutjnl-2011-300367. paper 24 6. Ciorba MA, Stenson WF. Probiotic Therapy in Radiation-Induced Intestinal Injury and Repair. Annals of the New York Academy of Sciences. 2009;1165(1):190-194. doi:10.1111/j.1749-6632.2009.04029.x. paper 23 7. Cui M, Xiao H, Zhou L, et al. Faecal microbiota transplantation protects against radiation induced toxicity. EMBOpress. 2017. doi: 10.15252/emmm.201606932. paper 2 8. Dubin K, Callahan MK, Ren B, et al. Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis. Nature Communications. 2016;7:10391. doi:10.1038/ncomms10391. paper 5 9. Galloway-Pena JR, Jenq RR, Shelburne SA. Can Consideration of the Microbiome Improve Antimicrobial Utilization and Treatment Outcomes in the Oncology Patient? Clinical Cancer Research. 2017. doi:10.1158/1078-0432.ccr-16-3173. paper 8 10. Iida N, Dzutsev A, S

Do People Who Are Trafficking Human Organs Help Other People? Essay

Do People Who Are Trafficking Human Organs Help Other People? (The Guardian, 2012), Denis Campbell and Nicola Davison, says that the unlawful business in human organs special kidneys has advanced quickly and unexpectedly. The reasons why selling kidneys has advanced quickly is that nowadays many countries have wars so there are many poor people who need money to live a good life. Also, after wars, there are many sick people that felt desperation because they lost their organs in the war and no one donated to them, so they needed to buy organs to stay alive. Other reason is because people have two kidneys so when they sell one kidney for important reasons, they won’t die. Most countries punish those people who sell their organs that is why in those countries there are many illegal trafficking of human organs, but in some countries trafficking human organs is legal like Iran. People who are trafficking human organs help other people to live a good life, also help sick people to feel healthy again and not to die. The desperation of many peo ple needing transplantation surgery and the poverty of many people with healthy organs often results in the trafficking of human organs. It’s a trade where the two persons win, because trafficking human organs help many poor people who don't have money to buy food or clothes by selling their organs that they can live without for money to the sick people who need this organ to stay alive. Selling organs can help the sick person to stay alive and give the poor person money to help his family from humiliating life. I read something posted on (ALL THINGS PAKISTAN blog, 2007) about a poor Pakistani guy who holds with his hand a paper with a sign that says â€Å"Would you buy my kidney please?.† I think ... ...can help many people. References All things pakistan blog. In (2007). Retrieved from http://pakistaniat.com/2007/10/17/would-you-like-to-buy-my-kidney-please/ Caplan, A. R., & Arp, R. (eds.) (2013). Contemporary debates in bioethics. Hoboken, NJ, USA: John Wiley & Sons. Retrieved from http://books.google.com.kw/books?id=-RsoAAAAQBAJ&dq=how much does the middle man make trafficking organs&source=gbs_navlinks_s Denis, C., & Davison, N. (2012). The guardian. In Shanghai : Retrieved from http://www.theguardian.com/world/2012/may/27/kidney-trade-illegal-operations-who Gross, R. (2008). Noblesse oblige blog. In Retrieved from http://noblesseoblige.org/2008/01/12/egyptian-man-sells-wives-kidney-on-black-market/ Parry, W. (2012). How poverty, false promises, fuel illegal organ trafficking. In Retrieved from http://www.livescience.com/19237-illegal-kidney-organ-trade.html Do People Who Are Trafficking Human Organs Help Other People? Essay Do People Who Are Trafficking Human Organs Help Other People? (The Guardian, 2012), Denis Campbell and Nicola Davison, says that the unlawful business in human organs special kidneys has advanced quickly and unexpectedly. The reasons why selling kidneys has advanced quickly is that nowadays many countries have wars so there are many poor people who need money to live a good life. Also, after wars, there are many sick people that felt desperation because they lost their organs in the war and no one donated to them, so they needed to buy organs to stay alive. Other reason is because people have two kidneys so when they sell one kidney for important reasons, they won’t die. Most countries punish those people who sell their organs that is why in those countries there are many illegal trafficking of human organs, but in some countries trafficking human organs is legal like Iran. People who are trafficking human organs help other people to live a good life, also help sick people to feel healthy again and not to die. The desperation of many peo ple needing transplantation surgery and the poverty of many people with healthy organs often results in the trafficking of human organs. It’s a trade where the two persons win, because trafficking human organs help many poor people who don't have money to buy food or clothes by selling their organs that they can live without for money to the sick people who need this organ to stay alive. Selling organs can help the sick person to stay alive and give the poor person money to help his family from humiliating life. I read something posted on (ALL THINGS PAKISTAN blog, 2007) about a poor Pakistani guy who holds with his hand a paper with a sign that says â€Å"Would you buy my kidney please?.† I think ... ...can help many people. References All things pakistan blog. In (2007). Retrieved from http://pakistaniat.com/2007/10/17/would-you-like-to-buy-my-kidney-please/ Caplan, A. R., & Arp, R. (eds.) (2013). Contemporary debates in bioethics. Hoboken, NJ, USA: John Wiley & Sons. Retrieved from http://books.google.com.kw/books?id=-RsoAAAAQBAJ&dq=how much does the middle man make trafficking organs&source=gbs_navlinks_s Denis, C., & Davison, N. (2012). The guardian. In Shanghai : Retrieved from http://www.theguardian.com/world/2012/may/27/kidney-trade-illegal-operations-who Gross, R. (2008). Noblesse oblige blog. In Retrieved from http://noblesseoblige.org/2008/01/12/egyptian-man-sells-wives-kidney-on-black-market/ Parry, W. (2012). How poverty, false promises, fuel illegal organ trafficking. In Retrieved from http://www.livescience.com/19237-illegal-kidney-organ-trade.html

Poverty in Philippines Essay

Life is a risking adventure. We commit a lot of obstacles and problems that sometimes pull our hopes down. Watching the documentary creates several feelings about the situations and it brings realizations after and while watching it. First of all, the documentary speaks about a family in Eastern Visayas wherein it reflects a serious poverty in the Philippines. The family experienced or still experiencing sufferings about their whole-life situation. The couples had ten sons and daughters all in all but only six of them were there current priorities. It must be easy for rich families to handle those six responsibilities but for them, it was a serious life challenge. Within a day, eating two meals is the best they can. Green vegetables with rice are considered a delightful meal for them. Because mostly, a piece of bread given by a neighbor or a soup considering rice mixed with water and salt was there food for breakfast while for lunch is still basing for the outcome of their unstable work. They are indeed suffering for poverty – or maybe beyond poverty. As an individual watching an uncommon documentary, I felt a lot of course. First, I felt pity for the whole family but mostly for the children. Children must be playing so free with a full tank – stomach with other kids, educating themselves in school, but what other children of their family do was working too, for the sake of the majority’s food. It was a punch on the heart to see those. Second, I feel so degraded yet fortunate. I am ashamed of myself because they really spend sweats and strengths for their daily benefits while most of us almost take spoon feed from our parents. But I felt so fortunate because even sometimes I feel so poor because of usual money-shortage; I realized how others’ seek hard for a one peso coin. Therefore, the documentary conscientisize most of us, but in a moral way I think. It aroused our conscience not to disgust ourselves because of realizations on mistakes but to change for the better. I am thinking that after watching the documentary, most of the viewer’s felt what I felt too, realized what I realized too, and will change as I’ll change. Starting now, I want to try giving importance with money. I want to encourage myself not to be hopeless in times of struggles. I’ll earn, try my best not to spoil and waste foods, and I will always ask for guidance to God for Him to help me conquer every obstacle. Because life is a risking adventure.

The Hundred Years War History and Summary

The Hundred Years War History and Summary The Hundred Years War was a series of connected conflicts between England, the Valois kings of France, factions of French nobles and other allies over both claims to the French throne and control of land in France. It ran from 1337 to 1453; you’ve not misread that, it is actually longer than a hundred years; the name derived from nineteenth-century historians and has stuck. Context of the Hundred Years War: English Land in France Tensions between the English and French thrones over continental land dated to 1066 when William, Duke of Normandy, conquered England. His descendants in England had gained further lands in France by the reign of Henry II, who inherited the County of Anjou from his father and control of the Dukedom of Aquitaine through his wife. Tensions simmered between the growing power of the French kings and the great power of their most powerful, and in some eyes equal, English royal vassal, occasionally leading to armed conflict. King John of England lost Normandy, Anjou, and other lands in France in 1204, and his son was forced to sign the Treaty of Paris ceding this land. In return, he received Aquitaine and other territories to be held as a vassal of France. This was one king bowing to another, and there were further wars in 1294 and 1324 when Aquitaine was confiscated by France and won back by the English crown. As the profits from Aquitaine alone rivaled those of England, the region was important  and retained many differences from the rest of France. Origins of the Hundred Years War When Edward III of England came to blows with David Bruce of Scotland in the first half of the fourteenth century, France supported Bruce, raising tensions. These rose further as both Edward and Philip prepared for war, and Philip confiscated the Duchy of Aquitaine in May 1337 in order to try and reassert his control. This was the direct start of the Hundred Years War. But what changed this conflict from the disputes over French land earlier was Edward III’s reaction: in 1340 he claimed the throne of France for himself. He had a legitimate right claim- when Charles IV of France had died in 1328 he was childless, and the 15-year-old Edward was a potential heir through his mother’s side, but a French Assembly chose Philip of Valois- but historians don’t know whether he really meant to try for the throne or was just using it as a bargaining chip to either gain land or divide the French nobility. Probably the latter but, either way, he called himself the King of France. Alternate Views As well as a conflict between England and France, the Hundred Years War can also be viewed as a struggle in France between the crown and major nobles for control of key ports and trading areas and equally a struggle between the centralizing authority of the French crown and local laws and independencies. Both are another stage in the development of the collapsing feudal/tenurial relationship between the King-Duke of England and the French King, and the growing power of the French crown/tenurial relationship between the King-Duke of England and the French King, and the growing power of the French crown. Edward III, the Black Prince and English Victories Edward III pursued a twofold attack on France. He worked to gain allies among disaffected French nobles, causing them to break with the Valois kings, or supported these nobles against their rivals. In addition, Edward, his nobles, and later his son- dubbed The Black Prince- led several great armed raids aimed at plundering, terrorizing and destroying French land, in order to enrich themselves and undermine the Valois king. These raids were called chevauchà ©es. French raids on the British coast were dealt a blow by the English naval victory at Sluys. Although the French and English armies often kept their distance, there were set-piece battles, and England won two famous victories at Crecy (1346) and Poitiers (1356), the second capturing the Valois French King John. England had suddenly won a reputation for military success, and France was shocked. With France leaderless, with large parts in rebellion and the rest plagued by mercenary armies, Edward attempted to seize Paris and Rheims, perhaps for a royal coronation. He took neither  but brought the Dauphin- the name for the French heir to the throne - to the negotiating table. The Treaty of Brà ©tigny was signed in 1360 after further invasions: in return for dropping his claim on the throne. Edward won a large and independent Aquitaine, other land and a substantial sum of money. But complications in the text of this agreement allowed both sides to renew their claims later on. French Ascendance and a Pause Tensions rose again as England and France patronized opposing sides in a war for the Castilian crown. Debt from the conflict caused Britain to squeeze Aquitaine, whose nobles turned to France, who in turn confiscated Aquitaine again, and war erupted once more in 1369. The new Valois King of France, the intellectual Charles V, aided by an able guerrilla leader called Bertrand du Guesclin, reconquered much of the English gains while avoiding any large pitch battles with the attacking English forces. The Black Prince died in 1376, and Edward III in 1377, although the latter had been ineffectual in his last years. Even so, the English forces had managed to check the French gains and neither side sought a pitched battle; stalemate was reached. By 1380, the year both Charles V and du Guesclin died, both sides were growing tired of the conflict, and there were only sporadic raids interspersed by truces. England and France were both ruled by minors, and when Richard II of England came of age he reasserted himself over pro-war nobles (and a pro-war nation), suing for peace. Charles VI and his advisors also sought peace, and some went on crusade. Richard then became too tyrannical for his subjects and was deposed, while Charles went insane. French Division and Henry V In the early decades of the fifteenth-century tensions rose again, but this time between two noble houses in France - Burgundy and Orlà ©ans - over the right to govern on behalf of the mad king. This division led to civil war in 1407 after the head of Orlà ©ans was assassinated; the Orlà ©ans side became known as the Armagnacs after their new leader. After a misstep where a treaty was signed between the rebels and England, only for peace to break out in France when the English attacked, in 1415 a new English king seized the opportunity to intervene. This was Henry V, and his first campaign culminated in the most famous battle in English history: Agincourt. Critics might attack Henry for poor decisions which forced him to fight a larger pursing French force, but he won the battle. While this had little immediate effect on his plans for conquering France, the massive boost to his reputation allowed Henry to raise further funds for the war and made him a legend in British history. Henry returned again to France, this time aiming to take and hold land instead of carrying out chevauchà ©es; he soon had Normandy back under control. The Treaty of Troyes and an English King of France The struggles between the houses of Burgundy and Orlà ©ans continued, and even when a meeting was agreed to decide upon anti-English action, they fell out once more. This time John, Duke of Burgundy, was assassinated by one of the Dauphin’s party, and his heir allied with Henry, coming to terms in the Treaty of Troyes in 1420. Henry V of England would marry the daughter of the Valois King, become his heir and act as his regent. In return, England would continue the war against Orlà ©ans and their allies, which included the Dauphin. Decades later, a monk commenting upon the skull of Duke John said: â€Å"This is the hole through which the English entered France.† The Treaty was accepted in English and Burgundian held lands- largely the north of France- but not in the south, where the Valois heir to France was allied with the Orlà ©ans faction. However, in August 1422 Henry died, and the mad French King Charles VI followed soon after. Consequently, Henry’s nine-month-old son became king of both England and France, albeit with recognition largely in the north. Joan of Arc Henry VI’s regents won several victories as they readied for a push into the Orlà ©ans heartland, although their relationship with the Burgundians had grown fractious. By September 1428 they were besieging the town of Orlà ©ans itself, but they suffered a setback when the commanding Earl of Salisbury was killed observing the city. Then a new personality emerged: Joan of Arc. This peasant girl arrived at the Dauphin’s court claiming mystic voices had told her she was on a mission to free France from English forces. Her impact revitalized the moribund opposition, and they broke the siege around Orlà ©ans, defeated the English several times and were able to crown the Dauphin in Rheims cathedral. Joan was captured and executed by her enemies, but opposition in France now had a new king to rally around. After a few years of stalemate, they rallied around the new king when the Duke of Burgundy broke with the English in 1435. After the Congress of Arras, they recognized Charles VII as king. Many believe the Duke had decided England could never truly win France. French and Valois Victory The unification of Orlà ©ans and Burgundy under the Valois crown made an English victory all but impossible, but the war continued. The fighting was halted temporarily in 1444 with a truce and a marriage between Henry VI of England and a French princess. This, and the English government ceding Maine to achieve the truce caused an outcry in England. War soon began again when the English broke the truce. Charles VII had used the peace to reform the French army, and this new model made great advances against English lands on the continent and won the Battle of Formigny in 1450. By the end of 1453, after all, English land bar Calais had been retaken and feared English commander John Talbot had been killed at the Battle of Castillon, the war was effectively over.

The Inventors Behind the Creation of Television

The Inventors Behind the Creation of Television Television wasnt invented by a single person. The efforts of many people working over the years, together and separately, contributed to the evolution of the technology. At the dawn of television history, two competing experimental approaches  led to the breakthroughs that eventually made the technology possible.  Early inventors attempted to build either a mechanical television based on Paul Nipkows rotating disks or an electronic television using a  cathode ray tube  developed independently in 1907 by English inventor A.A. Campbell-Swinton and Russian scientist Boris Rosing. Because electronic television systems worked better, they eventually replaced mechanical systems. Here is an overview of the major names and milestones behind one of the most important inventions of the 20th century. Mechanical Television Pioneers German inventor  Paul Gottlieb Nipkow developed a rotating disc technology in 1884 called the Nipkow disk to transmit pictures over wires. Nipkow is credited with  discovering televisions scanning principle, in which the light intensities of small portions of an image are successively analyzed and transmitted. In the 1920s, John Logie Baird patented the idea of using arrays of transparent rods to transmit images for television. Bairds 30-line images were the first demonstrations of television by reflected light rather than back-lit silhouettes.  Baird based his technology on Nipkows scanning disc idea and other developments in electronics. Charles Francis Jenkins invented a mechanical television system called Radiovision and claimed to have transmitted the earliest moving silhouette images on June 14, 1923. His company also  opened the first television broadcasting station in the U.S., named W3XK. Electronic Television Pioneers German scientist  Karl Ferdinand Braun entered history books by inventing the cathode ray tube (CRT) in 1897. This picture tube, which for years was the only device that could create the images viewers saw, was the basis for the advent of electronic television. In 1927, American Philo Taylor Farnsworth  became  the first inventor to transmit a television image- a dollar sign- comprising 60 horizontal lines. Farnsworth also developed the dissector tube, the basis of all current electronic televisions. Russian inventor  Vladimir Kosma Zworykin invented an improved cathode ray tube called the kinescope in 1929. Zworykin was one of the first to demonstrate a system with all the features that would come to make up televisions. Additional Television Components In 1947 Louis W. Parker invented the Intercarrier Sound System to synchronize television sound. His invention is used in all television receivers in the world. In June 1956  the TV remote controller first entered the American home. The first TV remote control, called Lazy Bones, was developed in 1950 by Zenith Electronics Corp., then known as Zenith Radio Corp. Marvin Middlemark invented rabbit ears, the once-ubiquitous V-shaped TV antennae, in 1953. His other inventions included a water-powered potato peeler and a rejuvenating tennis ball machine. Plasma TV display panels use small cells containing electrically charged ionized gases to generate high-quality imagery. The first prototype for a plasma display monitor was invented in 1964 by Donald Bitzer, Gene Slottow, and Robert Willson. Other Television Advances In 1925, Russian TV pioneer Zworykin filed a patent disclosure for an all-electronic color television system. Following authorization by the FCC, a color television system began commercial broadcasting on Dec. 17, 1953, based on a system invented by RCA. TV closed captions are hidden in the television video signal, invisible without a decoder. They were first demonstrated in 1972 and debuted the following year on the Public Broadcasting Service. Television content for the World Wide Web was rolled out in 1995. Historys first TV series made available on the Internet was  the public access program Rox.

Healthcare Policy Unit 2 DB HA415 Essay Example | Topics and Well Written Essays - 250 words

Healthcare Policy Unit 2 DB HA415 - Essay Example rces and efficient application of such resources identifies the importance of economics to health care policy makers because a good policy is one that can successfully be implemented. World Health Organization identifies the need to prioritize opportunities, or policies, and the need to solve the scarcity problem of resources through identification of sources, and efficient application of resources as some of the reasons why economics is important to policy makers in the health care sector. This is because every situation has alternative applicable policies and resources for implementing such policies are always scarce, and needed for application in other scopes. Consequently, there is a need for economic competence in order to identify a policy, with the highest level of utility, for implementation. Economics’ knowledge is further important to a health care policy maker because it facilitates identification of resources and efficient application of such resources in implement ation of an identified policy (World Health Organization, 2006). An understanding of economics is therefore important to a health care policy maker because it facilitates identification of policies with the highest utility level and ensures effective resource planning for policy

Kone's Strategic Plan Research Paper Example | Topics and Well Written Essays - 1750 words

Kone's Strategic Plan - Research Paper Example It will also show how KONE might use digital marketing as a competitive advantage. KONE is a very well reputed organization in the elevator and escalator industry. It is being noticed that in modern day business, digital marketing is playing a significant role. It is the need of the hour. Each and every global organization is understanding importance of digital marketing in their organizations. Digital marketing is such a promotional technique that, it can attract lots of customers within very short period of time. It reduces lots time and money for organizations. As an organization KONE faces the issue related with digital marketing. It is very important for the company to introduce digital marketing to maintain its competitive advantages. Long term vision, mission and corporate objectives are very important for every organization to excel in the future. KONE has very clear vision to provide best people flow experience. Here in this section mission statement and corporate objectives of the organization will be discussed. The organization measures their progress toward their vision. In course of that, they set some strategic targets. The organization has clear mission to acquire as many as loyal customers as possible. The company is very much committed to provide good working environment to their work forces. Sustainability and market leadership is a big priority for the organization. KONE has very significant corporate objectives. It wants to be a global market leader on the basis of technological innovation and creativity. Profitability and customer centricity is a very important characteristic of their corporate objective. The organization aims at long term higher financial growth than the normal industry standard. It wants to increase its global presence and want to satisfy different segments of their customers. The organization has decisive corporate objectives to match with different mega trends of the industry. Situation analysis has great